| Autor: |
Yuliannisa, H. P., Faridin, Benyamin, Andi Fachruddin, Bakri, Syakib, Makbul Aman, A., Kasim, Hasyim, Seweng, Arifin |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; May2020, Vol. 11 Issue 5, p802-806, 5p |
| Abstrakt: |
Introduction: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with a wide spectrum of clinical manifestations characterized by remissions and exacerbations. Serological tests are commonly used to assess the disease activity and predict lupus flare including complement (C3 and C4) test. During active disease, usually there is a fall in complement levels. However this tools are limited and require high cost. Some studies have shown lymphopenia tobe associated with disease activity and organ damage. The aim of the present study was to investigate the correlation between lymphopenia and disease activity (C3 and C4) in SLE patients. Method: A cross sectional analytic study included 27 patients who fulfilled the American College of Rheumatology (ACR) 1997 classification criteria for SLE was conducted. The patients were consecutively recruited from the Inpatient and outpatient of Dr. Wahidin Sudirohusodo Hospital and Private Rheumatology Clinic, Makassar. We collected lymphocyte count and complement C3 and C4 data from the patients. Results: The study included 27 SLE patients. This study shows the percentage of lymphopenia in low C3-C4 is higher than in normal C3-C4, which is 58.3% compared to 33.3%, but there is no statistically significant correlation between lymphopenia with low C3-C4 (p>0.05). The percentage of lymphopenia in low C3-normalC4 is higher than in normal C3-C4, which is 77.8% compared to 33.3%, but the results are also statistically insignificant (p> 0.05). Conclusions: Lymphopeniawas not significantly correlated with disease activity (C3 and C4) in SLE patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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