| Autor: |
Wooliscroft, Lindsey, Boespflug, Erin, Hildebrand, Andrea, Shangraw, Kathleen, Silbermann, Elizabeth, Bourdette, Dennis, Spain, Rebecca |
| Předmět: |
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| Zdroj: |
Multiple Sclerosis Journal - Experimental, Translational & Clinical; 10/13/2020, p1-4, 4p |
| Abstrakt: |
Background: In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods: Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results, Conclusion: In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = −2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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