| Autor: |
S., Kulkarni Nilesh, D., Gitte Pallavi, K., Munde Manojkumar, N., Dhole Shashikant |
| Předmět: |
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| Zdroj: |
Indian Drugs; Jul2020, Vol. 57 Issue 7, p70-73, 4p |
| Abstrakt: |
Deflazacort is a poorly water-soluble drug and is practically insoluble in water. The objective of this study was to improve the solubility of deflazacort by using as solubility enhancer ß-cyclodextrin and also to study the effect of the water-soluble polymer PEG 4000 on solubility of the deflazacort:ß-cyclodextrin binary system. The inclusion complexes of deflazacort with ß-cyclodextrin in 1:1 w/w, 1:2 w/w and 1:3 w/w proportions were prepared by kneading, microwave irradiation and freeze-drying techniques. The in vitro dissolution study showed improved dissolution rate for deflazacort for freeze-dried binary deflazacort: ß-cyclodextrin 1:2 w/w complex, as compared to ternary deflazacort:ß-cyclodextrin: PEG 6000 1:2 w/w complexes, plain deflazacort, physical mixtures and complexes prepared by kneading and microwave technique. This was confirmed by Fourier transform infrared spectroscopy, differential scanning calorimetry, powder x-ray diffraction study, scanning electron microscopy and 1H nuclear magnetic resonance spectroscopy study. Thus, deflazacort:ß-cyclodextrin complex with improved solubility was successfully developed using freeze drying technique. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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