Electrospun tubes based on PLA, gelatin and genipin in different arrangements for blood vessel tissue engineering.

Autor: Leyva-Verduzco, Abraham Alejandro, Castillo-Ortega, María Mónica, Chan-Chan, Lerma Hanaiy, Silva-Campa, Erika, Galaz-Méndez, Ramsés, Vera-Graziano, Ricardo, Encinas-Encinas, José Carmelo, Del Castillo-Castro, Teresa, Rodríguez-Félix, Dora Evelia, Santacruz-Ortega, Hisila del Carmen, Santos-Sauceda, Irela
Předmět:
Zdroj: Polymer Bulletin; Nov2020, Vol. 77 Issue 11, p5985-6003, 19p
Abstrakt: Four tubular membranes based on PLA and gelatin with different arrangements (PLA, gelatin, PLA-gelatin Blend and PLA/gelatin Core/Shell) were prepared by the electrospinning technique, the gelatin within the materials was crosslinked with genipin and all the meshes were characterized by SEM, ATR-FTIR, TGA, DSC, XRD and mechanical tests, also a viability essay and a confocal microscopy of HUVECs in contact with the materials were carried out. A 50% decrement of cellular viability was observed in the fibers with Core/Shell structure since the first day of culture compared with the tissue culture polystyrene, due to solubilization of non-crosslinked gelatin. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index