Design, Synthesis, Anti-Cancer Activity, and in silico Studies of Novel Imidazo[1,2-a]pyridine Derivatives.

Autor:	Endoori, S., Gulipalli, K. C., Bodige, S., Chandra, J. N. Narendra Sharath, Seelam, N.
Předmět:	IMIDAZOPYRIDINES PYRIDINE derivatives CELL lines HELA cells DRUG standards CELL growth
Zdroj:	Russian Journal of General Chemistry; Sep2020, Vol. 90 Issue 9, p1727-1736, 10p
Abstrakt:	A novel series of imidazo [1,2-a]pyridine derivatives has been designed, synthesized and tested for the anti-proliferative activity against three different human cancer cell lines. Most of the synthesized compounds exhibit anti-proliferative activity with IC50 values ranging from 5.35–59.8 μM. Six compounds demonstrate efficient inhibition of growth of all cell lines with IC50 values close to that of standard drug, and the compound 16h is more potent than the standard drug cisplatin for the HeLa cell line. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.