| Autor: |
Lu, Da‐Zhuang, Zhang, Yan‐Bo, Dong, Wei, Bi, Wen‐Juan, Feng, Xiao‐Jie, Wen, Li‐Ming, Sun, Hong, Chen, Hui, Zang, Lu‐Yang, Qi, Meng‐Chun |
| Předmět: |
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| Zdroj: |
Journal of Biomedical Materials Research, Part B: Applied Biomaterials; Nov2020, Vol. 108 Issue 8, p3402-3412, 11p |
| Abstrakt: |
Various bone substitutes have been applied in sinus augmentation (SA) to overcome insufficient bone height at the posterior maxilla region caused by pneumatized sinus and severe alveolar bone resorption after teeth loss. However, their effectiveness in SA needs to be further elucidated. In this study, strontium‐doped brushite (Sr‐DCPD), a new bone substitute, together with bovine‐derived hydroxyapatite (bHA) and synthetic hydroxyapatite (sHA) was used in rabbit maxillary SA with simultaneous implant installation. The sinus space‐keeping capacity, resorption rate, osteoconductivity, and mechanical properties of regenerated bone, were evaluated by micro‐computed tomography (CT), histological analysis, and mechanical testing. Sr‐DCPD exhibited the best osteoconductivity and new bone formation (<4 weeks), but its final bone regeneration and removal torque of implants at week 12 were the lowest, mainly due to its poor space‐keeping capacity and fast resorption. bHA exhibited the best space‐keeping capacity and slowest resorption rate, but relative lower final bone volume and mechanical properties, while sHA showed good space‐keeping capacity, slower resorption rate, and the best final bone formation and mechanical properties. sHA was most effective for SA and bHA was also an acceptable bone substitute; however, Sr‐DCPD was least effective and not suitable in SA by itself. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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