The immune modulator FTY720 targets sphingosine--kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.

Autor: Kaneider, Nicole C., Lindner, Julia, Feistritzer, Clemente, Sturn, Daniel H., Mosheimer, Birgit A., Djanani, Angela M., Wiedermann, Christian J.
Předmět:
Zdroj: FASEB Journal; Aug2004, Vol. 18 Issue 11, p1309-1311, 3p, 1 Diagram, 2 Graphs
Abstrakt: Presents an overview of a study which demonstrated that human monocyte migration toward Amyloidβ and Amyloid precursor protein involves activation of sphingosine kinase, which causes cell movement via S1P-independent mechanisms. Effects on signaling enzyme inhibitors on Amyloid-β-induced migration; Regulation of SIP receptor and messenger RNA expression by Amyloidβ; Discussion on sphingosine kinase activity and S1PR expression.
Databáze: Complementary Index