Magnetic Liposomes for Remote Controlled High-Molecular Drugs Release under a Low-Frequency Non-Heating Magnetic Field.

Autor: Vlasova, K. Yu., Vanzarakshaeva, S. Ch., Veselov, M. M., Le-Deygen, I. M., Petrunin, A. V., Prusov, A. N., Shuklinov, A. B., Golovin, Yu. I., Kabanov, A. V., Klyachko, N. L.
Zdroj: Moscow University Chemistry Bulletin; Jul2020, Vol. 75 Issue 4, p232-237, 6p
Abstrakt: Magnetic anionic liposomes (MALip) conjugated with magnetite magnetic nanoparticles (MNPs) are developed for the controlled release of a protease inhibitor (BBI) under exposure to a low-frequency nonheating magnetic field (LF AMF). It is shown that an increase of up to 35% of the protein release rate occurred when the MALip are exposed to the LF AMF (frequency 110 Hz, intensity 75–150 kA/m) for 5–15 min. The research provides prospects for the development of remotely controlled protein release from liposomes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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