Human NINEIN polymorphism at codon 1111 is associated with the risk of colorectal cancer.

Autor: Yasuda, Yukiko, Sakai, Akiko, Ito, Sachio, Sasai, Kaori, Ishizaki, Akisada, Okano, Yoshiya, Kawahara, Seito, Jitsumori, Yoshimi, Yamamoto, Hiromasa, Matsubara, Nagahide, Shimizu, Kenji, Katayama, Hiroshi
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Zdroj: Biomedical Reports; Nov2020, Vol. 13 Issue 5, pN.PAG-N.PAG, 1p
Abstrakt: NINEIN serves an essential role in centrosome function as a microtubule organizing center, and in the reformation of the interphase centrosome architecture following mitosis. In the present study, the association between NINEIN Pro1111Ala (rs2236316), a missense single nucleotide polymorphism, and the risk of colorectal cancer (CRC), related to smoking and alcohol consumption habits in 200 patients with CRC and 1,141 cancer-free control participants were assessed in a case-control study performed in Japan. The results showed that the NINEIN Ala/Ala genotype compared with the Pro/Pro genotype was significantly more associated with an increased risk of CRC, and the males with the Ala/Ala genotype exhibited a significantly increased risk of CRC compared with those with Pro/Pro and Pro/Ala genotypes. Stratified analyses of the Ala/Ala genotype with CRC risk further showed an increased association in never/light drinkers (<23 g of ethanol/day), in male never/light drinkers and in male patients with rectal cancer. These findings suggest that the genetic variant of the NINEIN Pro1111Ala polymorphism has a significant effect on CRC susceptibility in the Japanese population. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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