| Autor: |
Rizal, Dicky Moch., Sadewa, Ahmad Hamim, Natalia, Dhinar Mustika, Saragih, Hendri Trisakti, Ilmi, Miftahul, Nopitasari, Sri, Audinah, Liya, Widyasari, Annisaa, Sari, Mutiara Arum, Masri, Medina, Palilu, Prayolga Toban, Prabowo, Beni Hendro, Soleha, Siti, Solikhah, Annisa, Fitriana, Nita |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2020, Vol. 2260 Issue 1, p1-5, 5p |
| Abstrakt: |
The declines of male testosterone levels in aging process, reduce sexual and reproductive quality. Low testosterone levels are also associated with cardiovascular disease. Andropause is caused by non-hormonal factors (increased ROS, oxidative stress and decreased IGF-1). Oxidative stress and ROS will influence gene expression and inflammatory cytokines through NFκB activation. Increased expression of inflammatory cytokines causes a decrease in the biosynthesis of testosterone and an increase in atherogenic TGs. Platelet rich plasma (PRP) contain cytokines and growth factors are thought to act as therapy. The purpose of this study was to examine the effect of giving PRP to intratesticular COX-2 levels and serum TG levels of Wistar rats induced by D-Galactose (D-Gal). Samples of 30 male Wistar rats aged 3 months with body weight 200-300 gr: group K (control), P1 (D-Gal), P2 (D-Gal + 0.05 mL PRP), P3 (D-Gal + 0.1 mL PRP) and P4 (D-Gal + 0.2 mL PRP). Intraperitoneal injection of D-Gal dose of 300 mg/kg/day and intratesticular injection of PRP/7 days for 42 days. Group P1 was able to increase COX-2 levels. The PRP group had lower COX-2 and TG levels than the D-Gal group. COX-2 levels in D-Gal and PRP-induced rats were lower compared to rats without PRP. The forced difference is in the addition of 0.05 mL PRP. The difference in serum TG levels of rats before and after being induced with D-Gal was higher than that of mice induced by D-Gal and PRP. A significant decrease was found in all PRP groups with the highest value in the 0.2 mL PRP group. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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