Autor: |
Patil, P. S., Kasare, S. L., Badar, A. D., Kulkarni, R. S., Dixit, P. P., Kulkarni, J. A., Choudhari, P. B., Haval, K. P. |
Předmět: |
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Zdroj: |
Russian Journal of General Chemistry; Aug2020, Vol. 90 Issue 8, p1523-1528, 6p |
Abstrakt: |
A series of new (E)-1-[2-(2-ethylpyridin-4-yl)-4-methylthiazol-5-yl]-3-phenylprop-2-en-1-one derivatives have been synthesized starting from the antitubercular drug, ethionamide. The synthesized compounds have been tested for their in vitro antimicrobial activity, and five of those have demonstrated promising activity. According to molecular docking study the active compounds have display high binding affinity towards DNA Gyrase and Lumazine Synthase. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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