| Autor: |
Tiwari, Amit, Shrivastava, Nidhi, Shrivastava, N. M. |
| Předmět: |
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| Zdroj: |
International Journal of Pharmacy & Life Sciences; Jul2020, Vol. 11 Issue 7, p6751-6759, 9p |
| Abstrakt: |
During manufacturing of tablet dosage forms, monitoring of processing parameters of machines/equipments play an important role in inherent qualities of manufactured tablets. If these processing parameters are not controlled as per defined specifications mentioned in batch manufacturing record of said batch, then it will impact its ideal characteristics/physical properties as well as its performance and effectiveness in biological system. Therefore it is very important to monitor processing parameter like speed of compression machine during compression stage of tablet manufacturing. In this study, an attempt has been made to demonstrate impact of variation of processing parameter (compression machine speed) on ideal properties like weight variation, hardness, disintegration time and friability of tablet dosage form manufactured by using active materials of Ibuprofen, Loperamide Hydrochloride and Cetirizine Dihydrochloride. In this study individual tablet dosage forms have been formulated by using mentioned active drugs along with similar excipients. Individual tablets samples were collected after subjecting compression machine to slow, optimum and fast compression speed for carrying out respective in-process tests of weight variation, hardness, disintegration time and friability test. Thereafter an comparative analysis have been made through this study to demonstrate impact of compressing machine speed on ideal characteristics of tablet dosage forms. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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