| Autor: |
Righini, Andrea, Genovese, Maurilio, Parazzini, Cecilia, Severino, Mariasavina, Scola, Elisa, Pinelli, Lorenzo, Conte, Giorgio, Derrico, Ignazio, Di Maurizio, Marco, Talenti, Giacomo, Mandefield, Laura, Jarvis, Deborah, Palumbo, Giovanni, Guerrini, Renzo, Rossi, Andrea, Triulzi, Fabio, Griffiths, Paul D. |
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| Zdroj: |
European Radiology; Oct2020, Vol. 30 Issue 10, p5250-5260, 11p, 3 Black and White Photographs, 1 Diagram, 1 Chart, 2 Graphs |
| Abstrakt: |
Objective: To formulate a classification system for foetal cortical formation abnormalities (CFAs) based on in utero magnetic resonance (iuMR) appearances and trial it in 356 cases. Methods: This retrospective study included all cases of foetal CFA diagnosed between 2000 and 2017 from seven centres in Italy and UK. All of the studies were reviewed by a panel of paediatric neuroradiologists experienced in iuMR with the aid of an algorithm designed to categorise the abnormalities. Results: Consensus expert review confirmed 356 foetuses with CFA and the first level of classification distinguished bilateral CFA (229/356–64%) from unilateral CFA (127/356–36%) cases with sub-classification of the bilateral cases into asymmetric (65/356–18%) and symmetric (164/356–46%) involvement. There was a statistically significant excess of foetuses with small head size, e.g. 17% of the cohort had a bi-parietal diameter < 3rd centile. There was a small but statistically significant excess of males in the cohort. Further categorisation was made on fine anatomical structure. Conclusions: It is often not possible to classify foetal CFA using the principles and nomenclature used in paediatric neuroradiology. We have created a classification system for foetal CFA based on the analysis of 356 cases and believe that this will assist future research designed to correlate ante-natal and post-natal imaging features and understand the clinical sequelae of CFA described in utero. Key Points: • We describe a morphological classification system of foetal brain cortical formation abnormalities that can be used in clinical practice. • This classification system can be used in future research studies to evaluate the long-term imaging and clinical outcomes of foetal brain cortical formation abnormalities in 17- to 38-week gestational age range. • The practical value of the work is in providing a framework and language to look for imaging clues that may differentiate between different CFA in further studies. [ABSTRACT FROM AUTHOR] |
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Complementary Index |
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