Comparison of Efficacy and Safety of Two Tea Tree Oil-Based Formulations in Patients with Chronic Blepharitis: A Double-Blinded Randomized Clinical Trial.

Autor:	Ergun, Sule Berk, Saribas, Gulistan Sanem, Yarayici, Sait, Elmazoglu, Zubeyir, Cardak, Aziz, Ozogul, Candan, Ilhan, Mustafa Necmi, Karasu, Cimen, Evren Kemer, Ozlem
Předmět:	TEA tree oil BLEPHARITIS ESSENTIAL oils CLINICAL trials DEMODEX BOWEL preparation (Procedure) PROTEIN metabolism INTERLEUKINS RESEARCH BACTERICIDES EYELASHES MITES CHRONIC diseases ANIMAL experimentation RESEARCH methodology INTERLEUKIN-1 MEDICAL cooperation EVALUATION research TEARS (Body fluid) TREATMENT effectiveness COMPARATIVE studies RANDOMIZED controlled trials ENZYME-linked immunosorbent assay DRUGS BLIND experiment TUMOR necrosis factors PHARMACEUTICAL gels
Zdroj:	Ocular Immunology & Inflammation; 2020, Vol. 28 Issue 6, p888-897, 10p
Abstrakt:	Introduction: It was aimed to evaluate the efficacy of two tea tree oil (TTO)-based cleansing gels in chronic blepharitis patients.Methods: Group-1 (basic gel containing 3%(w/w)-TTO) included 50 eyes of 25 patients and group-2 (advanced gel containing 3%(w/w)-TTO plus essential oils and vitamins) included 48 eyes of 24 patients. Ocular Surface Disease Index (OSDI), tear breakup time (TBUT), ocular surface staining pattern, Schirmer's test, impression cytology, Demodex presence and TNF-α, IL-6, IL-1β levels were evaluated at the first visit and 1 month after treatment.Results: In both groups, the mean OSDI score decreased (p1:0.001, p2:0.001), TBUT increased (p1:0.002, p2:0.004). In group-1, Demodex presence decreased from 42% to 27.8%; in group-2 from 54.2% to 20.6% (p1:0.302, p2:0.004). IL-1β and IL-6 decreased in group-2 (p1:0.002, p2:0.050). TNF-α decreased in both groups (p1:0.001, p2:0.001).Conclusion: Both formulations improved ocular surface parameters. Group 2 showed more reduction in tear cytokines and Demodex count. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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