| Abstrakt: |
Aim: The aim of this study was to evaluate the in vitro antimicrobial efficacy of Catharanthus roseus leaf extract against standard strains of periodontal pathogens, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia. Methodology: The C. roseus leaves were identified, shade dried, and ground, and ethanol extract was obtained. The antimicrobial efficacy of this extract was done using disc diffusion assay, minimum inhibitory concentration, and minimum bactericidal concentration. Results: C. roseus leaf extract showed antimicrobial activity against all the three test organisms. However, P. gingivalis was found to be more susceptible to C. roseus leaf extracts, since their growth was inhibited at relatively lower concentration as compared to A. actinomycetemcomitans and P. intermedia. Conclusion: Within the limitations of the study, the present results have provided preliminary scientific evidence for the development of antimicrobial products, and further studies and clinical trials need to be performed. [ABSTRACT FROM AUTHOR] |
