Do Calcium and Potassium Levels Influence Ductal Patency in Preterm Infants?

Autor: Cakir, Ufuk, Tayman, Cuneyt, Buyuktiryaki, Mehmet, Unsal, Handan, Ozer Bekmez, Buse
Předmět:
Zdroj: American Journal of Perinatology; 2020, Vol. 37 Issue 11, p1123-1129, 7p
Abstrakt: Objective  We investigated the relationship of serum potassium (K +) and ionized calcium (iCa 2+) levels with the persistence of ductus arteriosus. Study Design  This retrospective cohort study included infants with birth weight < 1,500 g and gestational age < 32 weeks. Serum K + and iCa 2+ levels at the 1st and 48th hour of life were measured from samples. The difference between the two levels was calculated for both serum K + (ΔK +) and iCa 2+ (ΔCa 2+). These values were compared between hemodynamically significant patent ductus arteriosus (hsPDA) and non-hsPDA. Results  Of 1,322 hospitalized preterm nonates, 1,196 were included in the study. Mean serum K + levels at the 1st and 48th hour were higher and iCa 2+ levels at the 1st and 48th hour were lower in hsPDA and non-hsPDA, respectively (p  < 0.001). Ionized ΔCa 2+ (–0.06 ± 0.13 vs. –0.02 ± 0.12 mmol/L) was higher in hsPDA (p  < 0.001). Conclusion  We demonstrated that serum K + and iCa 2+ level might play a role in ductal constriction. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index