| Autor: |
Stojanović, Stevan D, Fiedler, Jan, Bauersachs, Johann, Thum, Thomas, Sedding, Daniel G |
| Zdroj: |
European Heart Journal; 8/14/2020, Vol. 41 Issue 31, p2983-2996, 14p, 5 Diagrams, 1 Chart |
| Abstrakt: |
Inflammation is a hallmark and potent driver of pathological vascular remodelling in atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown mixed results. As an alternative perspective on the conundrum of chronic inflammation emerging evidence points towards a small subset of senescent cells as a critical player and central node driving atherosclerosis. Senescent cells belonging to various cell types are a dominant and chronic source of a large array of pro-inflammatory cytokines and various additional plaque destabilizing factors, being involved with various aspects of atherosclerosis pathogenesis. Antagonizing these key agitators of local chronic inflammation and plaque instability may provide a causative and multi-purpose therapeutic strategy to treat atherosclerosis. Anti-senescence treatment options with translational potential are currently in development. However, several questions and challenges remain to be addressed before these novel treatment approaches may enter the clinical setting. Open in new tab Download slide Open in new tab Download slide [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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