| Autor: |
Zaidi, Faseeh, Narang, Ravi K, Phipps-Green, Amanda, Gamble, Greg G, Tausche, Anne-Katherin, So, Alexander, Riches, Philip, Andres, Mariano, Perez-Ruiz, Fernando, Doherty, Michael, Janssen, Matthijs, Joosten, Leo A B, Jansen, Tim L, Kurreeman, Fina, Torres, Rosa J, McCarthy, Geraldine M, Miner, Jeffrey N, Stamp, Lisa K, Merriman, Tony R, Dalbeth, Nicola |
| Předmět: |
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| Zdroj: |
Rheumatology; Sep2020, Vol. 59 Issue 9, p2544-2549, 6p |
| Abstrakt: |
Objective The aim of this study was to examine whether serum urate-associated genetic variants are associated with early-onset gout. Methods Participants with gout in the Genetics of Gout in Aotearoa study with available genotyping were included (n = 1648). Early-onset gout was defined as the first presentation of gout <40 years of age. Single nucleotide polymorphisms (SNPs) for the 10 loci most strongly associated with serum urate were genotyped. Allelic association of the SNPs with early-onset gout was tested using logistic regression in an unadjusted model and in a model adjusted for sex, body mass index, tophus presence, flare frequency, serum creatinine and highest serum urate. The analysis was also done in two replication cohorts: Eurogout (n = 704) and Ardea (n = 755), and data were meta-analysed. Results In the Genetics of Gout in Aotearoa study, there were 638 (42.4%) participants with early-onset gout. The ABCG2 rs2231142 gout risk T-allele was present more frequently in participants with early-onset gout compared with the later-onset group. For the other SNPs tested, no differences in risk allele number were observed. In the allelic association analysis, the ABCG2 rs2231142 T-allele was associated with early-onset gout in unadjusted and adjusted models. Analysis of the replication cohorts confirmed the association of early-onset gout with the ABCG2 rs2231142 T-allele, but not with other serum urate-associated SNPs. In the meta-analysis, the odds ratio (95% CI) for early-onset gout for the ABCG2 rs2231142 T-allele was 1.60 (1.41, 1.83). Conclusion In contrast to other serum urate-raising variants, the ABCG2 rs2231142 T-allele is strongly associated with early-onset gout. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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