| Autor: |
Barendregt, Anouk M, Veldkamp, Saskia R, Muller, Petra C E Hissink, van de Geer, Annemarie, Aarts, Cathelijn, Gulik, E Charlotte van, Schilham, Marco W, Kessel, Christoph, Keizer, Mischa P, Hemke, Robert, Rashid, Amara Nassar-Sheikh, Dolman, Koert M, Schonenberg-Meinema, Dieneke, Cate, Rebecca ten, Berg, J Merlijn van den, Maas, Mario, Kuijpers, Taco W |
| Předmět: |
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| Zdroj: |
Rheumatology; Sep2020, Vol. 59 Issue 9, p2392-2401, 10p |
| Abstrakt: |
Objective To study two neutrophil activation markers, myeloid-related protein (MRP) 8/14 and neutrophil elastase (NE), for their ability to predict treatment response and flare in patients with JIA. Methods Using samples from two cohorts (I and II), we determined MRP8/14 and NE levels of 32 (I) and 81 (II) patients with new-onset, DMARD-naïve arthritis and compared patients who responded to treatment (defined as fulfilling ≥ adjusted ACRpedi50 response and/or inactive disease) with non-responders (defined as fulfilling < adjusted ACRpedi50 response and/or active disease) at 6 and 12 months. Secondly, we compared biomarker levels of 54 (I) and 34 (II) patients with clinically inactive disease who did or did not suffer from a flare of arthritis after 6 or 12 months. Receiver operating characteristic analyses were carried out to study the predictive value of MRP8/14 and NE for treatment response and flare. Results For both cohorts, baseline MRP8/14 and NE levels for patients who did or did not respond to treatment were not different. Also, MRP8/14 and NE levels were not different in patients who did or did not flare. Receiver operating characteristic analysis of MRP8/14 and NE demonstrated areas under the curve <0.7 in both cohorts. Conclusion In our cohorts, MRP8/14 and NE could not predict treatment response. Also, when patients had inactive disease, neither marker could predict flares. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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