| Autor: |
Makurina, Olga Nikolaevna, Kartashov, Valery Panteleevich, Notina, Elena Alexandrovna, Bykova, Irina Alexandrovna, Terekhin, Alexey Alexeyevich |
| Předmět: |
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| Zdroj: |
Indian Journal of Public Health Research & Development; Mar2020, Vol. 11 Issue 3, p1748-1753, 6p |
| Abstrakt: |
Context: Purpose: to find out age-related changes in the micro-rheological characteristics of red blood cells in rats after hypothermia. The study included 88 healthy outbred male rats at the age of 6 months. Prior to inclusion in the study, all rats were healthy and did not participate in the studies. Animals experienced an episode of hypothermia - within 1 hour at a temperature of -10ºС. The control group consisted of 32 healthy outbred male rats of a similar age. The study was conducted using biochemical, hematological and statistical research method. In rats subjected to hypothermia, an increase in the activity level of free radical oxidation processes in plasma lipids and red blood cells was found. Over time, a decrease in the level of erythrocyte-discocytes was observed in the blood of the observed rats, which was most pronounced in rats one month after hypothermia. This was accompanied by an increase in their level of changed reversibly and irreversibly erythrocyte forms and an increase in spontaneous aggregation of red blood cells. In rats, after an episode of hypothermia, a gradual weakening of the plasma antioxidant defense develops. In these rats, aggregation readiness and the degree of change in the surface properties of red blood cells progressively increased. Apparently, this creates a risk in animals of a progressive increase in morbid burden and weakening of the whole organism in relation to resistance to negative environmental influences. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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