A general strategy for degradable single-chain nanoparticles via cross-linker mediated chain collapse of radical copolymers.

Autor: Jackson, Alexander W., Chennamaneni, Lohitha Rao, Mothe, Srinivasa Reddy, Thoniyot, Praveen
Předmět:
Zdroj: Chemical Communications; 9/4/2020, Vol. 56 Issue 68, p9838-9841, 4p
Abstrakt: Radical ring-opening copolymerization (rROP) between 2-methylene-1,3-dioxepane (MDO) and methacrylic acid N-hydroxysuccinimide ester (NHSMA) furnishes a reactive polyester-based linear copolymer precursor. Subsequent cross-linker mediated chain collapse affords degradable single-chain nanoparticles (DSCNPs). This methodology is an experimentally robust and straightforward route to main-chain degradable polymeric nanoparticles in the sub-30 nm size range. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index