| Autor: |
Sancesario, Giulia Maria, Di Lazzaro, Giulia, Alwardat, Mohammad, Biticchi, Benedetta, Basile, Valerio, Salimei, Chiara, Colona, Vito Luigi, Sinibaldi Salimei, Paola, Bernardini, Sergio, Mercuri, Nicola Biagio, Pisani, Antonio, Schirinzi, Tommaso, Canevelli, Marco |
| Předmět: |
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| Zdroj: |
Journal of Alzheimer's Disease; 2020, Vol. 76 Issue 3, p1171-1178, 8p |
| Abstrakt: |
Background: Synaptopathy is critical in pathophysiology of Parkinson's disease (PD). Cerebrospinal fluid (CSF) levels of neurogranin (NG) and amyloid-β42 (Aβ42) are considered markers of synaptic dysfunction in neurodegenerative diseases.Objective: To evaluate the CSF synaptopathy-related biomarkers, especially the novel Aβ42/NG ratio, in PD, establishing possible associations with cognitive level and other clinical parameters.Methods: Levels of NG, Aβ42, amyloid-β40, total and phosphorylated tau, and Aβ42/NG ratio were measured in 30 PD patients and 30 controls and correlated with cognitive and motor parameters. The accuracy in distinguishing the cognitive status was determined.Results: NG and Aβ42 were significantly reduced in PD, with higher NG levels in patients with worse cognition. The Aβ42/NG ratio showed a direct correlation with Mini-Mental State Examination, independently from age and sex, and differentiated cognitively impaired patients with 92% sensitivity and 71.4% specificity, accuracy higher than NG alone. No correlations resulted with motor disturbances or therapy.Conclusions: The novel Aβ42/NG ratio couples either presynaptic or postsynaptic markers of synaptic dysfunction, representing a potential global index of synaptopathy, useful to track cognitive functions in PD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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