Association of Promoter Region Polymorphisms of IL-6 and IL-18 Genes with Risk of Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis.

Autor: Salimi, Erfaneh, Karimi-Zarchi, Mojgan, Dastgheib, Seyed Alireza, Abbasi, Hajar, Tabatabaiee, Razieh Sadat, Hadadan, Amaneh, Amjadi, Nooshin, Akbarian-Bafghi, Mohammad Javad, Neamatzadeh, Hossein
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Zdroj: Fetal & Pediatric Pathology; Aug2020, Vol. 39 Issue 4, p346-359, 14p
Abstrakt: Background: The present meta-analysis was performed to investigate the association of promoter region polymorphisms at IL-6 and IL-18 genes with recurrent pregnancy loss (RPL) risk. Methods: An electronic search of the PubMed, Embase, ISI Web of Knowledge and CNKI databases was performed to identify eligible studies up to May 30, 2019. Results: A total of 31 case-control studies were finally selected. Significant associations with the risk of RPL were detected for the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms in overall population. Further, subgroup analyses by ethnicity revealed that the IL-6 -174 G > C and -634 G > C polymorphisms were significantly associated with risk of RPL risk in Asians. Conclusions: Our results suggest that the IL-6 -174 G > C, -634 G > C and IL-18 -137 G > C polymorphisms may contribute to the susceptibility of RPL. The IL-18 -607 C > A polymorphism does not appear to influence the development of RPL. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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