EFFECT OF A NOVEL ANTIMICROBIAL PEPTIDE (KK-20) IN COMBINATION WITH ANTIBIOTICS ON PSEUDOMONAS AERUGINOSA.

Autor: Panwar, Rekha, Kumar, Ram, Basant, Gahlot, Kritika, Purva, Mukul, Maherchandani, Sunil
Předmět:
Zdroj: Veterinary Practitioner; Dec2019, Vol. 20 Issue 2, p147-149, 3p
Abstrakt: In the present study a novel antimicrobial peptide identified from β defensin of Tharparkar breed of cattle in our laboratory was studied for its efficacy in combination with two antibiotics (Gentamicin and Ceftazidime) on Pseudomonas aeruginosa isolates. Both the antibiotics in combination with KK-20 gave a synergistic effect against Pseudomonas aeruginosa, however the extent of the effect varied with both the antibiotics. KK-20 in combination with Ceftazidime, was highly effective against both planktonic and biofilm form of bacteria where as in combination with the Gentamicin it showed synergistic effect only against planktonic form as there was reduction in minimal inhibitory concentraton. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index