| Autor: |
Li, Deng-Yuan, Chen, Jia-Yan, Feng, Da-Fu, Chen, Shuang, Xu, Xian-Kuan, Dang, Li, Liu, Pei-Nian |
| Předmět: |
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| Zdroj: |
Chemical Communications; 7/28/2020, Vol. 56 Issue 59, p8222-8225, 4p |
| Abstrakt: |
A transition-metal-free double addition/double rearrangement domino reaction affording CF3-substituted pyrimidines was developed, which enables the one-pot construction of five new bonds, namely three C–C bonds and two C–N bonds. The keys to achieve this highly efficient reaction include the delicate design of the bis-nucleophiles in situ generated from the dimerization of alkyl nitriles and the use of trifluoroacetimidoyl nitriles containing C＝N, C≡N, and CF3 groups as the reactant. The mechanistic studies by the experiments and DFT calculations reveal that the transformation involves two addition and two unprecedented rearrangement processes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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