New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440.

Autor:	Nur, Elyza Aiman Azizah, Kobayashi, Keisuke, Amagai, Ai, Ohshiro, Taichi, Tomoda, Hiroshi
Předmět:	STRUCTURE-activity relationships ISOENZYMES INDOLINONE DITERPENES SPINE INDOLE
Zdroj:	Molecules; Jul2020, Vol. 25 Issue 13, p3079-3079, 1p, 6 Diagrams, 3 Charts
Abstrakt:	New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440. The structures of 1–3 were elucidated using various spectroscopic experiments including 1D- and 2D-NMR. All compounds 1–3 contained a common indole–diterpene backbone. Compounds 2 and 3 had 7 and 6 consecutive ring systems with an indole ring, respectively, whereas 1 had a unique indolinone plus 4 consecutive ring system. Compounds 2 and 3 inhibited both sterol O-acyltransferase 1 and 2 isozymes, but 1 lost the inhibitory activity. Structure–activity relationships of fungal indole–diterpene compounds are discussed. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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