| Autor: |
Wang, Changbing, Chen, Yi, Xu, Tiantian, Tian, Xingui, Zheng, Jianbin, Liu, Wenkuan, Xia, Yu, Li, Yinghua, Zhu, Bing, Zhou, Rong |
| Předmět: |
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| Zdroj: |
Journal of Medical Virology; Aug2020, Vol. 92 Issue 8, p1059-1064, 6p |
| Abstrakt: |
Enterovirus A71 (EV‐A71) is one of the main pathogens causing hand, foot, and mouth disease, and often causes diseases of the central nervous system. Early diagnosis is important to prevent EV‐A71 outbreaks. The detection of serum immunoglobulin M (IgM) is widely used for the early diagnosis of EV‐A71 in clinics, especially in rural areas. However, this technique requires the extraction of blood from children who have thin blood vessels and who might fear the use of needles. Therefore, difficulties in the detection process are often encountered. This study developed a noninvasive method to detect EV‐A71‐specific immunoglobulin A (IgA) in saliva for the diagnosis of EV‐A71 infection. The sensitivity and specificity of IgA detection did not differ significantly compared with IgM detection. IgA antibodies were present in saliva for a relatively shorter period than IgM antibodies were present in serum. The sensitivity of IgA detection was higher than that of IgM detection for secondary EV‐A71 infections. These results suggest that the detection of EV‐A71‐specific IgA in the saliva allows the effective early diagnosis of EV‐A71 and may be suitable for detecting EV‐A71 infections in children. Highlights: Anti‐EV‐A71 IgA antibodies are present in saliva for 3 weeks, less than IgM antibodies are present in serum.Saliva IgA is more sensitive than serum IgM in detecting secondary EV‐A71 infections.Detection of EV‐A71‐specific IgA in saliva is noninvasive.Saliva EV‐A71‐specific IgA is a suitable diagnostic method for EV‐A71 infection in children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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