Clinical significance of blue‐green neutrophil and monocyte cytoplasmic inclusions in SARS‐CoV‐2 positive critically ill patients.

Autor: Cantu, Miguel D., Towne, William S., Emmons, Foxwell N., Mostyka, Maria, Borczuk, Alain, Salvatore, Steven P., Yang, He S., Zhao, Zhen, Vasovic, Ljiljana V., Racine‐Brzostek, Sabrina E.
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Zdroj: British Journal of Haematology; Jul2020, Vol. 190 Issue 2, pe89-e92, 4p, 1 Chart, 1 Graph
Abstrakt: Keywords: blue-green inclusions; COVID-19; lactic acid; liver injury; SARS-CoV-2 EN blue-green inclusions COVID-19 lactic acid liver injury SARS-CoV-2 e89 e92 4 07/20/20 20200715 NES 200715 Identification of blue-green cytoplasmic inclusions in neutrophils and/or monocytes on peripheral blood smears is a rare, and likely underreported, finding described in few case reports and small case series studies in critically ill patients with acute liver dysfunction and lactic acidosis.1-11 As these inclusions are thought to herald poor prognosis and death shortly after identification, they have been referred to as "green crystals of death" or "critical green inclusions". Here we describe six critically ill patients diagnosed with SARS-CoV-2 infection during the COVID-19 pandemic in New York City who all died within days of these peculiar blood smear findings. Within 21 days, six patients who tested positive for SARS-CoV-2 by real-time polymerase chain reaction (PCR) from a nasopharyngeal swab specimen at presentation were found to have blue-green leukocyte inclusions on routine peripheral blood smears. Blue-green inclusions, COVID-19, lactic acid, liver injury, SARS-CoV-2. [Extracted from the article]
Databáze: Complementary Index