| Abstrakt: |
Previous studies supposed that rosemary may have a suppressive effect on the thyroid, but there were no investigations on the ameliorative effect of rosemary (Rosemarinus officinyroialis) leaves extract in the treatment of hyperthyroidism. Thus, we declared the validity of this hypothesis in the regulation of thyroid gland function in particular hyperthyroidism induced in rats by L-thyroxine. This study attempts to declare if rosemary (Rosemarinus officinyroialis) extract supplementation exhibits antithyroid effects in hyperthyroid rats or not. Twenty-eight animals were divided into (4) groups, each group with seven albino male rats. Group I (control) rats were received distilled water at 0.1 ml/day/animal orally and served as a negative control. Twenty-one rats in Groups (II, III and IV) were rendered hyperthyroid by daily administration of L-thyroxine at a dose of 500µg/kg subcutaneously for 12 consecutive days. From the 13th day to the 24th day, Group II (hyperthyroid) receive only distilled water at 0.1 ml/day/animal orally and served as a positive control, Group III (propylthiouracil treated) were administered propylthiouracil (10 mg/kg orally) while, Group IV (rosemary treated) were administered rosemary extract (10 mg/kg orally). Serum T2, T2 and TSH activity in hyperthyroidism and treated male rats are present in Table 1. The results showed that PTU and rosemary T1 and T2 respectively caused a significant (P<0.05) decrease in serum T4 activity in treated groups as compared to the negative and positive control groups. While serum T3 activity decreases significantly (P<0.05) in groups T1 and T2 as compared with C2 and non-significant (P>0.05) differences between T2 and C1. Also, nonsignificant (P>0.05) differences in TSH activity were observed in groups T2, T2, C1 and C2 when compared to each other. It is concluded that rosemary (Rosemarinus officinyroialis) leaves extract improved suppressive effect on the thyroid in male rats. Thus, it may be used as a potential source of drug for the treatment of hyperthyroidism. However, further investigations are required. [ABSTRACT FROM AUTHOR] |
