| Autor: |
Chougale, U. B., Chavan, H. V., Deshmukh, S. M., Kharade, P. R., Dhongade, S. R. |
| Předmět: |
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| Zdroj: |
Rasayan Journal of Chemistry; Jul-Sep2020, Vol. 13 Issue 3, p1506-1512, 7p |
| Abstrakt: |
A series of aryl pyrazole-indanone hybrids were synthesized by the Knoevenagel condensation of 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde 4 with various 1-indanones 5 at room temperature. The structural investigations were carried out with IR, ¹H NMR and mass spectral data. All the newly synthesized compounds were assessed for their anticancer and antimicrobial properties. Among the compounds screened 6d, 6e and 6f displayed moderate anticancer potential against MCF-7 (IC50 42.6-53.9 µM). On the other hand compounds 6a, 6b, 6c, 6d and 6g unveiled potent activity against S. aureus and compound 6c and 6b displayed moderate activity against E. coli. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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