| Autor: |
Shirsand, Shailashri S., Shirsand, Sidramappa B., Aute, Sunil, Amruta, Deshpande, Raghunandan |
| Předmět: |
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| Zdroj: |
Manipal Journal of Pharmaceutical Sciences; Mar2020, Vol. 6 Issue 1, p8-14, 7p |
| Abstrakt: |
The present work aims to improve patient compliance with fast dissolving lorazepam tablets by the direct compression procedure. The method used crospovidone and croscarmellose sodium (2-8% weight by weight (w/w) as super-disintegrants in solitary as well as disintegrating mixtures (i.e., crospovidone-croscarmellose sodium, crospovidone-sodium starch glycolate), and to enhance the mouth feel, directly compressible mannitol was used. In the prepared tablet formulations, lorazepam estimates were performed Ultraviolet(UV)/ Visible spectroscopic method at 231 nm. The preparation formulations were further assessed for friability, hardness, wetting time, water absorption, drug content uniformity and in vitro dispersion time. Based on the in-vitro dispersion time of around 12-42 s, in vitro drug release patterns (6.8 phosphate buffer), stability studies (3 months; at 40 °C/75% relative humidity) and drug excipient interactions (Infrared(IR) spectroscopy) were tested for promising formulations. The formulation (containing disintegrant blends of 2% w/w crospovidone and 4% w/w croscarmellose sodium) emerged as the overall best formulation among all the promising formulations. Stability studies on the promising formulation indicated that the drug content and the time of dispersion in vitro were not significantly changed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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