| Autor: |
Hemmati, Ali Asghar, Rashidi, Iran, Dahanzadeh, Sedigheh, Moeini, Mahmoud |
| Předmět: |
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| Zdroj: |
Journal of Contemporary Medical Sciences; Mar/Apr2020, Vol. 6 Issue 2, p66-72, 7p |
| Abstrakt: |
Objective This research designed to investigate the wound healing process with pomegranate hydroalcoholic seed extract (Punica granatum) in comparison with no-treatment, betamethasone, phenytoin, and eucerin in rabbits. Methods The positive group including groups that received phenytoin cream (1%) and topical eucerin, respectively, twice a day to complete wound healing. negative control group did not obtain any treatment. Treatment groups were received cream of pomegranate seed extract (PSE) (2, 5,7,10 w/w) in eucerin and 75% w/w as purified extract twice daily. In order to measure the percentage of wound healing, the zone of the wound was evaluated daily. Histological studies were done on the 7th and 15th days of treatment. Next, hydroxyproline content of wounds healed and tensile strength of wound tissue samples were measured. Results The results demonstrated between PSE treatment groups and eucerin animals were statistically significant different (P<0.05) in most of the days reviewed. Treatment of rabbits with 10% PSE had the best results (complete wound recovery in 12 days). Also, this treatment showed higher hydroxyproline content and higher tissue strength. Conclusion This research reveals that the extract of 10% PSE administrated topically has the proper potential to induce wound recovery in the wound model of rabbits. In addition, 10% PSE accelerates the healing of the wound. Further study needs to clarify the results of this research. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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