Cationic Dendrimer G2-S16 Inhibits Herpes Simplex Type 2 Infection and Protects Mice Vaginal Microbiome.

Autor: Guerrero-Beltrán, Carlos, Garcia-Heredia, Inmaculada, Ceña-Diez, Rafael, Rodriguez-Izquierdo, Ignacio, Serramía, María Jesús, Martinez-Hernandez, Francisco, Lluesma-Gomez, Mónica, Martinez-Garcia, Manuel, Muñoz-Fernández, María Ángeles
Předmět:
Zdroj: Pharmaceutics; Jun2020, Vol. 12 Issue 6, p515, 1p
Abstrakt: The G2-S16 polyanionic carbosilane dendrimer is a promising microbicide that inhibits HSV-2 infection in vitro and in vivo in mice models. This G2-S16 dendrimer inhibits HSV-2 infection even in the presence of semen. Murine models, such as BALB/c female mice, are generally used to characterize host-pathogen interactions within the vaginal tract. However, the composition of endogenous vaginal flora remains largely undefined with modern microbiome analyses. It is important to note that the G2-S16 dendrimer does not change healthy mouse vaginal microbiome where Pseudomonas (10.2–79.1%) and Janthinobacterium (0.7–13%) are the more abundant genera. The HSV-2 vaginally infected female mice showed a significant microbiome alteration because an increase of Staphylococcus (up to 98.8%) and Escherichia (30.76%) levels were observed becoming these bacteria the predominant genera. BALB/c female mice vaginally-treated with the G2-S16 dendrimer and infected with the HSV-2 maintained a healthy vaginal microbiome similar to uninfected female mice. Summarizing, the G2-S16 polyanionic carbosilane dendrimer inhibits the HSV-2 infection in the presence of semen and prevents the alteration of mice female vaginal microbiome. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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