| Abstrakt: |
Introduction: Breast cancer is the most common cancer among women. Today, various studies have examined the preference of two methods, Hematoxylin and eosin (H&E) and Immunohistochemistry (IHC) in the study of breast biopsies, but there is always a difference of opinion between There are studies on this. Therefore, in this study, we compared the two methods of staining (H&E) and IHC staining in differentiating different types of proliferative and neoplastic lesions in breast biopsies based on the observer agreement coefficient. Materials and Methods: In this cross-sectional study, 81 breast biopsy specimens of patients with various types of proliferative and neoplastic lesions in the breast were among patients referred to Al-Zahra, Seyed Al- Shohada and Kashani hospitals in Isfahan during a 5-year period since 2014. It was done until 1397. Samples were observed using H&E staining and IHC staining by two pathologists, and their agreement was assessed using the Kappa coefficient. Results: According to the Kappa test, the agreement between the two pathologists about H&E staining (p <0.001, kappa = 0.82) and IHC staining (p <0.001, kappa = 0.95) was directly significant. Conclusion: Given that the level of agreement between the two pathologists in the IHC staining method is higher than the H&E staining, it seems that the IHC staining method has a more favorable efficiency in the study of proliferative and neoplastic breast lesions. [ABSTRACT FROM AUTHOR] |
