| Abstrakt: |
Background and objectives Blood donors are the essential pillars for safe blood transfusion service. This study aimed to analyse the spectrum of blood donor adverse events (AE) and design strategies for their prevention; to improve donor safety and increase donation frequency; and to encourage the establishment of a donor vigilance across different blood centres. Material and methods A prospective study was conducted within the Department IHBT over eighteen months on whole blood (voluntary/replacement) and aphaeresis donors who were selected as per the national guidelines. Statistical analysis was done using Spss software. Results Altogether, 576 AE were observed in 11 371 donors, with significantly higher rate in plateletpheresis [61 in 314 donors] than WB donation. First time (451/4551), replacement (172/2894), female (158/1535) and young donors (18– 40 years) (485/7969) were significantly prone to AE. Generalized vasovagal reactions (n = 349) were the commonest AE followed by haematoma. The onset of AE was mainly during postdonation period. Vasovagal reactions were significantly high in first time (P = 0·0001), replacement (P = 0·0001), female (P = 0·0001), young (18–40 years) (P = 0·0001) and low body weight donors (45–54 kg) (P = 0·0001) when compared to repeat, voluntary, male, older and heavier donors. Haematoma was found significantly higher in aphaeresis [P = 0·0001], first time [P = 0·0001] and heavier donors [P = 0·0001] as compared to WB, repeat and low body weight donors. Conclusion We attempted to identify the spectrum of donor AE at our institution and also propose certain preventive measures, which would help in reducing the frequency of these AE. It is an evidence-based approach to guide other blood centres and motivate them to establish their own donor vigilance. [ABSTRACT FROM AUTHOR] |
