Carbon Tetrachloride, Alcohol and Ranitidine Induced Hepatotoxicity and Its Protection by Bark Extracts of Bassia Latifolia in Wister Rats.

Autor: Thimmaraju, Manish Kumar, Mondal, Prasenjit, Venu, Kola, Padmaja, Bookya, Babu, Gummadi Sridhar, Dinesh Kumar, Rudra, Ravi Kumar, Konda
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Zdroj: Journal of Herbs, Spices & Medicinal Plants; 2020, Vol. 26 Issue 3, p275-290, 16p
Abstrakt: The hepatoprotective activity of bark extracts of Bassia latifolia in carbon tetrachloride (CCl4), ethyl alcohol (ALC) or ranitidine (RTD) induced hepatotoxicity in rats were examined. Acute toxicity study (LD50) was conducted with the highest dose of 2,000 mg kg−1 b.w. in mice. The model animals were divided into nine groups with six animals in each. Standard Silymarin was used as reference in each model. Phytochemical screening of ethanolic extract of bark of B. latifolia (EEBBL) and aqueous extract of bark of B. latifolia (AQEBBL) revealed the presence of glycosides, tannins, saponins, triterpenoids and flavonoids in both the extracts. When these extracts were subjected to LD50 studies neither one produced abnormal behavior or mortality at 2,000 mg kg−1 b.w. in mice. Silymarin, EEBBL and AQEBBL treated groups increased Thiopentone-induced sleeping time (TST), wet liver weight and volume. Alanine transferase (ALT), Aspartate amino transferase (AST), alkaline phosphatese (ALP), direct bilirubin (BILD), total bilirubin (BILT), albumin (ALB), protein (PRO), Cholesterol (CHO) and triglyceride (TG), levels were reduced, and ALB and PRO levels were increased. The histopathological changes were partly or fully prevented. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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