| Autor: |
Khalil, A., Sotiriadis, A., Chaoui, R., da Silva Costa, F., D'Antonio, F., Heath, P.T., Jones, C., Malinger, G., Odibo, A., Prefumo, F., Salomon, L. J., Wood, S., Ville, Y. |
| Předmět: |
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| Zdroj: |
Ultrasound in Obstetrics & Gynecology; Jul2020, Vol. 56 Issue 1, p128-151, 24p |
| Abstrakt: |
Despite the fact that case reports of intrauterine herpes simplex virus (HSV) infection have been published, this infection is not included herein, as the majority of neonatal HSV infections are acquired at birth as a consequence of direct fetal contact with the infected birth canal or through an ascending infection after premature rupture of the amniotic membranes. CMV infection may be acquired for the first time during pregnancy (primary infection) or it may result from reactivation of prior infection or reinfection with a different strain of the virus (non-primary infection). Nevertheless, a retrospective study of women with maternal primary infection in the index pregnancy found that, once the diagnosis of fetal infection had been made by PCR confirmation of CMV in the amniotic fluid, ultrasound was found to be more sensitive for the detection of subtle abnormalities associated with the fetal infection[18]. In common with other viral infections, however, the risk of an infected fetus being affected (i.e. risk of developing congenital defects) is greatest when infection occurs earlier in gestation: it is 97% when infection is before 12 weeks and 20% when it is from 12 to 16 weeks, while infection from 16 to 20 weeks is associated with a minimal risk of deafness only[[123], [142], [144]]. Diagnosis of fetal rubella infection Recommendations When primary infection occurs before 12 weeks' gestation, given the risk of fetal infection and the risk of an infected fetus developing severe abnormalities, termination of pregnancy can be considered, even without invasive testing ( B GOOD PRACTICE POINT b ). [Extracted from the article] |
| Databáze: |
Complementary Index |
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