| Abstrakt: |
Objective: Alzheimer's disease (AD), Lewy body disease (LBD), and white matter disease (WMD) are common in the elderly. Although these diseases are observed together pathologically, the extent to which these diseases occur together clinically is uncertain. To address this question, we analyzed the clinical neuroimaging data of Japanese patients. Patients and Methods: This was a prospective study with a 3.0‐year recruiting period, a prospective follow‐up period of 2.0 ± 1.5 years, and ≥1×/year visits. We recruited 770 referred subjects who had undergone three neuroimaging markers: brain magnetic resonance imaging (MRI), dopamine transporter (DAT) scanning, and metaiodobenzylguanidine (MIBG) myocardial scintigraphy. Results: Among the 770 patients, 731 fulfilled the criteria of some of or all of the three diseases as follows: WMD (n = 46), WMD + AD (n = 110), WMD + LBD (n = 89), WMD + AD +LBD (n = 86), AD (n = 118), LBD (n = 239), and AD + LBD (n = 43). In total, there were patients with WMD (n = 331), AD (n = 357), and LBD (n = 414) (with overlap); dual diseases (n = 242; 33%) and triple diseases (n = 86; 12%). Clinically, pure WMD showed overactive bladder but mild gait/cognitive disorder. Pure AD showed cognitive disorder alone. Pure LBD showed cognitive, gait, and sleep/autonomic disorders. Triple/dual diseases showed combined clinical features, depending on the underlying diseases. However, these differences did not reach statistical significance. Conclusion: Forty‐five percent of the patients who visited dementia/movement disorder/sleep‐autonomic disorder clinics showed either triple or dual diseases. It is important to follow such patients from the viewpoint of disease progression and necessary care. [ABSTRACT FROM AUTHOR] |
