| Autor: |
Gurbuz, Abdurrahman, Alkan, Muzaffer, Manap, Sevda, Ozdemir, Gul, Kol, Ozlem Gursoy, Yuksek, Haydar |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical, Chemical & Biological Sciences; Jan-May2020, Vol. 10 Issue 1, p1-8, 8p |
| Abstrakt: |
A series of novel 3-alkyl(aryl)-4-[2-(2-thienylcarbonyloxy)-3-methoxybenzylideneamino]-4,5- dihydro-1H-1,2,4-triazol-5-ones (4) were synthesized from the reactions of 3-alkyl(aryl)-4- amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) with 2-(2-thienylcarbonyloxy)-3-methoxybenzaldehyde (3). Then, the acetylation reactions of compounds 3 were investigated and 1- acetyl-3-alkyl(aryl)-4-[2-(2-thienylcarbonyloxy)-3-methoxybenzylideneamino]-4,5-dihydro-H- 1,2,4-triazol-5-ones (5) were obtained. The structures of thirteen new compounds were characterized from IR, 1H NMR, 13C NMR and UV spectral data. In addition, the synthesized new 4 and 5 type compounds were analyzed for their in vitro potential antioxidant activities in three different methods; including 1,1-diphhenlyl-2-picryl-hydrazyl free radical (DPPH.) scavenging, reducing activity by Fe+3 - Fe+2 transformation and ferrous metal (Fe+2) chelating activities [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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