Synthesis, Structure and Biological Activity of Coordination Compounds of Copper, Nickel, Cobalt, and Iron with Ethyl N'-(2-Hydroxybenzylidene)-N-prop-2-en-1-ylcarbamohydrazonothioate.

Autor:	Gulea, А. P., Usataia, I. S., Graur, V. О., Chumakov, Yu. M., Petrenko, P. A., Balan, G. G., Burduniuc, O. S., Tsapkov, V. I., Rudic, V. F.
Předmět:	COORDINATION compounds IRON compounds COPPER chlorides COPPER compounds MORPHOLOGY NICKEL COBALT IRON-nickel alloys
Zdroj:	Russian Journal of General Chemistry; Apr2020, Vol. 90 Issue 4, p630-639, 10p, 8 Diagrams, 6 Charts
Abstrakt:	N-(Prop-2-en-1-yl)hydrazonocarbothioamide reacts with iodoethane in methanol with further addition of 2-hydroxybenzaldehyde to form hydroiodide of carbamohydrazonothioate (HL·HI). The coordination compounds were obtained by interaction of HL or HL·HI with copper, nickel, cobalt and iron salts CuLХ·nH2O [X = Cl–, Br–, NO3–; n = 0–1], Ni(L)2·HI·CH3OH, Сo(L)2X [X = I–, NO3–] and Fe(L)2NO3. The structures of three complexes were established by single crystal X-ray analysis. The synthesized complexes exhibit selective antimicrobial and antifungal activity against a series of standard microorganisms and fungi in the concentration range of 30–500 μg/mL. In addition, nickel and iron complexes selectively inhibit the growth and proliferation of cancer cells and do not adversely affect normal cells. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz: