Reduction in All-Cause Mortality with Fluticasone Furoate/Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease.
| Autor: | Lipson, David A, Crim, Courtney, Criner, Gerard J, Day, Nicola C, Dransfield, Mark T, Halpin, David M G, Han, MeiLan K, Jones, C Elaine, Kilbride, Sally, Lange, Peter, Lomas, David A, Lettis, Sally, Manchester, Pamela, Martin, Neil, Midwinter, Dawn, Morris, Andrea, Pascoe, Steve J, Singh, Dave, Wise, Robert A, Martinez, Fernando J |
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| Předmět: |
FLUTICASONE
OBSTRUCTIVE lung diseases MORTALITY SECONDARY analysis ACQUISITION of data THERAPEUTIC use of glucocorticoids STEROID drugs BENZENE derivatives ADRENERGIC beta agonists CAUSES of death RESEARCH COMBINATION drug therapy HETEROCYCLIC compounds RESEARCH methodology EVALUATION research MEDICAL cooperation SEVERITY of illness index COMPARATIVE studies FORCED expiratory volume ALCOHOLS (Chemical class) INHALATION administration MUSCARINIC antagonists PROPORTIONAL hazards models |
| Zdroj: | American Journal of Respiratory & Critical Care Medicine; 6/15/2020, Vol. 201 Issue 12, p1508-1516, 9p |
| Abstrakt: | Rationale: The IMPACT (Informing the Pathway of Chronic Obstructive Pulmonary Disease Treatment) trial demonstrated a significant reduction in all-cause mortality (ACM) risk with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) versus UMEC/VI in patients with chronic obstructive pulmonary disease (COPD) at risk of future exacerbations. Five hundred seventy-four patients were censored in the original analysis owing to incomplete vital status information.Objectives: Report ACM and impact of stepping down therapy, following collection of additional vital status data.Methods: Patients were randomized 2:2:1 to FF/UMEC/VI 100/62.5/25 μg, FF/VI 100/25 μg, or UMEC/VI 62.5/25 μg following a run-in on their COPD therapies. Time to ACM was prespecified. Additional vital status data collection and subsequent analyses were performed post hoc.Measurements and Main Results: We report vital status data for 99.6% of the intention-to-treat population (n = 10,355), documenting 98 (2.36%) deaths on FF/UMEC/VI, 109 (2.64%) on FF/VI, and 66 (3.19%) on UMEC/VI. For FF/UMEC/VI, the hazard ratio for death was 0.72 (95% confidence interval, 0.53-0.99; P = 0.042) versus UMEC/VI and 0.89 (95% confidence interval, 0.67-1.16; P = 0.387) versus FF/VI. Independent adjudication confirmed lower rates of cardiovascular and respiratory death and death associated with the patient's COPD.Conclusions: In this secondary analysis of an efficacy outcome from the IMPACT trial, once-daily single-inhaler FF/UMEC/VI triple therapy reduced the risk of ACM versus UMEC/VI in patients with symptomatic COPD and a history of exacerbations. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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