Effects of turmeric extract supplementation on inflammation and muscle damage after a half-marathon race: a randomized, double-blind, placebo-controlled trial.

Autor: Faria, Flávia Rasmussen, Gomes, Aline Corado, Antunes, Alisson, Rezende, Kênnia Rocha, Pimentel, Gustavo Duarte, Oliveira, Camila Lemos Pinto, Antunes, Barbara Moura, Lira, Fabio Santos, Aoki, Marcelo Saldanha, Mota, João Felipe
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Zdroj: European Journal of Applied Physiology; Jul2020, Vol. 120 Issue 7, p1531-1540, 10p, 2 Charts, 4 Graphs
Abstrakt: Purpose: Strenuous exercise induces inflammation and muscle damage. Turmeric (Curcuma longa L.) is a widely used spice that exhibits potent anti-inflammatory response and appears to decrease indirect markers of muscle damage. A randomized, double-blind, placebo-controlled trial was conducted to evaluate the effects of Curcuma longa L. extract (CLE) on inflammation and muscle damage after a half-marathon race.Methods: Twenty-eight healthy, normal-weight men were randomly assigned to one of two groups: (1) CLE (3 capsules per day, 500 mg each); or (2) placebo (PLA, 3 capsules per day, 500 mg of microcrystalline cellulose). Participants received the intervention for 4 weeks and immediately before and after the half-marathon race. Creatine kinase, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, myoglobin, interleukins 6 and 10 were assessed at baseline, immediately before, after, and at 2, 24, and 48 h after the half-marathon race.Results: The half-marathon race increased markers of inflammation and muscle damage. A greater increase in interleukin-10 was observed in the CLE group immediately after the competition compared to the PLA group (7.54 ± 1.45 vs 5.25 ± 0.59 pg/mL; p < 0.05; d = 0.55). Myoglobin concentration was lower 2 h after the race in participants from the CLE group compared to the PLA group (62.10 ± 8.26 vs 107.85 ± 18.45 ng/mL; p = 0.01; d = 0.86).Conclusion: Curcuma longa L. extract supplementation leads to an increase in IL-10 and decreased myoglobin in recreational male runners after a half-marathon race.Trial Registration Number: U1111-1179-6335, February 13, 2016. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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