The friendly use of chloroquine in the COVID-19 disease: a warning for the G6PD-deficient males and for the unaware carriers of pathogenic alterations of the G6PD gene.

Autor: Capoluongo, Ettore D., Amato, Felice, Castaldo, Giuseppe
Předmět:
Zdroj: Clinical Chemistry & Laboratory Medicine; Jul2020, Vol. 58 Issue 7, p1162-1164, 3p
Abstrakt: Keywords: Chloroquine; COVID-19; G6PD EN Chloroquine COVID-19 G6PD 1162 1164 3 06/15/20 20200701 NES 200701 To the Editor, I In vitro i data suggest that chloroquine (the most used antimalarial drug) inhibits SARS CoV-2 replication as many previous papers have shown as this molecule displays an I in vitro i activity against various viruses (e.g. chikungunya virus), although without any reliable benefit in animal models [[1]]. Administering hydroxychloroquine or other chloroquine salts to elderly patients with I G6PD i deficiency represents a higher risk to generate adverse effects due to these medications. [Extracted from the article]
Databáze: Complementary Index