| Autor: |
De Weerdt, Annick, Janssen, Bram G., Cox, Bianca, Bijnens, Esmée M., Vanpoucke, Charlotte, Lefebvre, Wouter, El Salawi, Omar, Jans, Margot, Verbrugghe, Walter, Nawrot, Tim S., Jorens, Philippe G. |
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| Zdroj: |
Intensive Care Medicine; Jun2020, Vol. 46 Issue 6, p1204-1212, 9p, 1 Diagram, 3 Charts, 1 Graph |
| Abstrakt: |
Purpose: Air pollutant exposure constitutes a serious risk factor for the emergence or aggravation of (existing) pulmonary disease. The impact of pre-intensive care ambient air pollutant exposure on the duration of artificial ventilation was, however, not yet established.Methods: The medical records of 2003 patients, admitted to the intensive care unit (ICU) of the Antwerp University Hospital (Flanders, Belgium), who were artificially ventilated on ICU admission or within 48 h after admission, for the duration of at least 48 h, were analyzed. For each patient's home address, daily air pollutant exposure [particulate matter with an aerodynamic diameter ≤ 2.5 µm (PM2.5) and ≤ 10 µm (PM10), nitrogen dioxide (NO2) and black carbon (BC)] up to 10 days prior to hospital admission was modeled using a high-resolution spatial-temporal model. The association between duration of artificial ventilation and air pollution exposure during the last 10 days before ICU admission was assessed using distributed lag models with a negative binomial regression fit.Results: Controlling for pre-specified confounders, an IQR increment in BC (1.2 µg/m3) up to 10 days before admission was associated with an estimated cumulative increase of 12.4% in ventilation duration (95% CI 4.7-20.7). Significant associations were also observed for PM2.5, PM10 and NO2, with cumulative estimates ranging from 7.8 to 8.0%.Conclusion: Short-term ambient air pollution exposure prior to ICU admission represents an unrecognized environmental risk factor for the duration of artificial ventilation in the ICU. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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