| Autor: |
Quan, Lingli, Luo, Xiping, Xue, Liangjun, Li, Jiaping, Ouyang, Yudan |
| Předmět: |
|
| Zdroj: |
Journal of Inorganic & Organometallic Polymers & Materials; Jul2020, Vol. 30 Issue 7, p2744-2755, 12p |
| Abstrakt: |
In the research, two novel coordination polymers based on Cu(II) ion as the metal source and their nanostructures have been prepared via utilizing two ligands of positional isomeric pyridine carboxylic acid 2-(5-carboxypyridin-3-yl)terephthalic acid (H3L2) and 4-(6-carboxypyridin-3-yl)phthalic acid (H3L1) under the conditions of ultrasonic and solvothermal reaction, and their chemical formulas are {[Cu3(L1)2(H2O)6](H2O)7}n (1) along with {[Cu3(L1)2(H2O)2](H2O)2}n (2). In addition, the treatment effect of 1 and 2 on the human cancer in vitro and in vivo was detected. The Cell Counting Kit-8 (CCK8) method was used to determine the proliferation of human lung cancer cell line (NCI-H292) after nanoparticles 1–2 treatment, the results exhibited that nanoparticle 1 had excellent inhibitory function on NCI-H292 cell viability. Besides, ROS accumulation in the NCI-H292 cells was detected by reactive oxygen species (ROS) assay and annexin V-FITC/PI assay was conducted to detect the apoptotic cells numbers of NCI-H292 cells induced by nanoparticles 1–2 treatment. In addition, the tumor model was established in vivo and the treatment ability of the nanoparticle on NCI-H292 tumor was evaluated by measuring the mice weight and tumor volume. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink