| Autor: |
Zheng, Gang, Zheng, Fanghong, Luo, Zucheng, Ma, Haiwei, Zheng, Dongdong, Xiang, Guangheng, Xu, Cong, Zhou, Yifei, Wu, Yaosen, Tian, Naifeng, Wu, Yan, Zhang, Tan, Ni, Wenfei, Wang, Sheng, Xu, Huazi, Zhang, Xiaolei |
| Předmět: |
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| Zdroj: |
Frontiers in Pharmacology; 6/4/2020, Vol. 11, p1-11, 11p |
| Abstrakt: |
Spinal cord injury (SCI) is a clinical tough neurological problem without efficient cure currently. Blood-spinal cord barrier (BSCB) interruption is not only a crucial pathological feature for SCI process but is a possible target for future SCI treatments; however, few treatments have been developed to intervene BSCB. In the present study, we intravenously injected CO-releasing molecule3 (CORM-3), a classical exogenous CO donor, to the rats experiencing SCI and assessed its protection on BSCB integrity in rats. Our results demonstrated that the exogenous increasing of CO by CORM-3 blocked the tight junction (TJ) protein degeneration and neutrophils infiltration, subsequently suppressed the BSCB damage and improved the motor recovery after SCI. And we certified that the CO-induced down-regulation of MMP-9 expression and activity in neutrophil might be associated with the NF-κB signaling. Taken together, our study indicates that CO-releasing molecule (CORM)-3 ameliorates BSCB after spinal cord injury. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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