Y-CHROMOSOME MICRODELETION AND MALE-INFERTILITY.

Autor: Babu, K. Ranjith, Bhutkar, Milind V., Shastri, Deepti, Manivannan, E.
Předmět:
Zdroj: Journal of Advanced Scientific Research; 2020, Vol. 11 Issue 2, p25-33, 9p
Abstrakt: Infertility is a multifactorial condition prevalent across the globe and a draws attention of whole world. Infertility is a concern as it may be due to idiopathic and may be due to congenital or acquired. Infertility is a condition in couple of young age which can be defined as failure to achieve pregnancy even after 12 months or more of regular unprotected sexual intercourse. A systematic search for the literature published was conducted in the MEDLINE-Pubmed database. The inclusion filters were ‘Y chromosome deletions and male infertility’. Among the search results, the titles and abstracts of all the articles were screened for eligibility and relevance of the topic are selected as per the inclusion and exclusion criteria. After analyzing the above article we can say that Y chromosome has more chances of microdeletions which may be due to presence of palindrome structures with a more chances of homologous recombination among ampliconic sequences. It is also found that the prevalence or occurrence of Y-chromosome microdeletions in male infertile patients is varied throughout the world. Y-chromosome occurrence varied to a very high 75.68% to a low value of 0%. We can suggest that during the treatment of any infertility case, subsequent testing for any Y-chromosome microdeltions has to be done routinely before proceeding for any ART as it may result in carrying the same microdeletion to the next generation. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index