Nanogel receptors for high isoelectric point protein detection: influence of electrostatic and covalent polymer–protein interactions.

Autor: Wechsler, Marissa E., Dang, H. K. H. Jocelyn, Dahlhauser, Samuel D., Simmonds, Susana P., Reuther, James F., Wyse, Jordyn M., VandeWalle, Abigail N., Anslyn, Eric V., Peppas, Nicholas A.
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Zdroj: Chemical Communications; 6/7/2020, Vol. 56 Issue 45, p6141-6144, 4p
Abstrakt: An aldehyde acrylate-based functional monomer was incorporated into poly(N-isopropylacrylamide-co-methacrylic acid) nanogels for use as protein receptors. The aldehyde component forms dynamic imines with surface exposed lysine residues, while carboxylic acid/carboxylate moieties form electrostatic interactions with high isoelectric point proteins. Together, these interactions effect protein adsorption and recognition. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index