Sonographic evaluation of renal changes among drug-dependent and drug-naive adult patients with human immunodeficiency virus/acquired immunodeficiency syndrome in Kano, Nigeria.

Autor: Sidi, Mohammed, Ugwu, Anthony, Dambatta, Abdu, Saleh, Mohammed, Jibo, Umar, Jega, Muhammad, Aminu, Aminu, Ya'u, Anas, Mansur, Umar
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Zdroj: Nigerian Journal of Basic & Clinical Sciences; Jan-Jun2020, Vol. 17 Issue 1, p26-32, 7p
Abstrakt: Context: Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) remains a major challenge globally. HIVassociated nephropathy is the third most common cause of endstage renal failure and more prevalent among AfricanAmericans with HIV compared with other races. Aims: This study evaluated sonographic renal changes in drugdependent and drugnaive patients with HIV/AIDS in Kano, Nigeria.Materials and Methods: A prospective and comparative study involving 190 each of drugdependent and drugnaïve patients were conducted. Renal sonography was performed using digital ultrasonic diagnostic imaging system, equipped with a 3.5 MHz curvilinear transducer. Statistical analysis used: An independent ttest and Mann–Whitney Utest were used to compare the renal volume and mean rank of the renal parenchymal echogenicity between drugdependent and drugnaïve patients. Statistical significance was considered at P < 0.05. Results: The mean values of the CD4 counts were 573.20 ± 222.441 cells/mm3 for drugdependent and 252.43 ± 215.22 cells/mm3 for drugnaïve patients. The drugdependent and drugnaïve patients had mean right renal volumes of 118.12 ± 27.75 cm3 and 128.48 ± 37.73 cm3, whereas the left renal volumes were 114.84 ± 24.14 cm3 and 123.35 ± 28.22 cm3, respectively. The drugdependent patients had 6.3% and 4.7% increased renal parenchymal echogenicity on the right and left, whereas the drugsnaïve patients had 45.3% and 43.7%, respectively. There was a statistically significant difference in the right and left renal volume between drugdependent and drugnaïve patients (P = 0.003 and P = 0.002). There was a significant statistical difference in the right and left renal parenchymal echogenicity between drugdependent and drugnaïve patients (P = 0.00). Conclusions: There was a significant statistical difference in the renal volume and parenchymal echogenicity between drugdependent and drugnaïve patients. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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