Histology of the Torn Meniscus: A Comparison of Histologic Differences in Meniscal Tissue Between Tears in Anterior Cruciate Ligament -- Intact and Anterior Cruciate Ligament-Deficient Knees.

Autor: Meister, Keith, Indelicato, Peter A., Spanier, Suzanne, Franklin, John, Batts, Joel
Předmět:
Zdroj: American Journal of Sports Medicine; Sep2004, Vol. 32 Issue 6, p1479-1483, 7p
Abstrakt: Purpose: The purpose of this case control study was to evaluate possible preexisting structural differences between torn menisci in anterior cruciate ligament-intact and anterior cruciate ligament-deficient knees. Materials and Methods: Subjects were prospectively enrolled into the study from new patient referrals to the orthopaedic clinic. Forty-four meniscal specimens were retrieved during routine arthroscopy. The anterior cruciate ligament-deficient group included 24 patients (15 men and 9 women, average age of 26.5 years, SD 9.5) with 24 acute, displaced, longitudinal, bucket-handle tears of the medial meniscus in unstable, anterior cruciate ligament-deficient knees. The anterior cruciate ligament-intact group included 20 patients (14 men and 6 women, average age of 30.4 years, SD = 13.4) with similar tears in anterior cruciate ligament- intact knees. Longitudinal and transverse section specimens were stained with hematoxylin and eosin and safranin 0, divided into zones based on proximity to the tear, and graded on safranin 0 uptake or tissue composition. Results: Descriptive statistics and X2 analyses were used to assess differences between groups within each zone. Significant differences (P < .05) were observed between anterior cruciate ligament-deficient and anterior cruciate ligament-intact specimens stained with hematoxylin and eosin in zone 3 for both transverse and longitudinal cuts. Significant differences were not found between anterior cruciate ligament-deficient and anterior cruciate ligament-intact specimens stained with safranin O. Conclusion: Longitudinal meniscal tears occurring in anterior cruciate ligament-intact knees may result from early degenerative disease processes. Attempted repair of this diseased tissue may fail to have a positive effect on long-term preservation of the meniscus. [ABSTRACT FROM AUTHOR]
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